Martyna Filipska – ESR 5

 

Main Host Institution: Germans Trias i Pujol Health Sciences Institute

Host Lab: Cancer Biology and Precision Medicine

Project Background: CD47 is a well-known “don’t eat me” protein that when expressed on cancer cells, leads to immune-evasion and inhibition of phagocytosis by macrophages. CD47 was recently also found present on the surface of exosomes. The composition of exosome-surface markers is known to mimic that of the cell of origin, and therefore to carry a cell-specific cargo with functional properties, like microRNAs (miRNAs).

Project Aim:

The aim of the project is miRNA profiling in CD47-enriched exosomes for establishment of a miRNA panel to predict response for immunotherapy at the baseline, but also to assess early response after treatment, mainly to control the risk of severe adverse effects before they appear.

Contact: mfilipska@igtp.cat